Portal latinoamericano de toxicología
RCTs in Therapeutics letter
19 October, 2007
Clinical implications of recent key therapeutic trials. Therapeutics letter (ca) . July – August 2007
Randomised controlled clinical trials (RCTs) are critical in determining the net health effect of a therapy (benefit minus harm).When the primary outcome of the trial is the reduction in one or more serious
adverse events, the best measure of the net health effect of the drug is the total number of people with at least one serious adverse event (see Therapeutics Letter 42). When the total number of people with at least one serious adverse event is not reported, total mortality is the next best measure of net health effect. In this Letter we use this analytic perspective to interpret the results and clinical implications of four recent RCTs. [ Read more ]
Randomised controlled clinical trials (RCTs) are critical in determining the net health effect of a therapy (benefit minus harm).When the primary outcome of the trial is the reduction in one or more serious
adverse events, the best measure of the net health effect of the drug is the total number of people with at least one serious adverse event (see Therapeutics Letter 42). When the total number of people with at least one serious adverse event is not reported, total mortality is the next best measure of net health effect. In this Letter we use this analytic perspective to interpret the results and clinical implications of four recent RCTs. [ Read more ]