WONCA  Global Family Doctor, comment an article: "Currently there is no approved pharmacotherapy for amphetamine dependence. Recent human laboratory studies have demonstrated that naltrexone modulates some of the reinforcing effects of amphetamine. In this 12-week randomized controlled trial by Swedish investigators naltrexone 50 mg was compared with placebo to reduce relapse in 80 amphetamine-dependent patients. Patients visited the clinic twice weekly to receive medication and relapse prevention therapy and leave urine samples, which were analyzed for drug toxicology and for assessing adherence to medication via detection of naltrexone’s metabolite (naltrexol). Larger and longer trials are needed".

Naltrexone for the Treatment of Amphetamine Dependence: A Randomized, Placebo-Controlled Trial. Jayaram-Lindstrom N, Hammarberg A, Beck O, Franck J. . Am J Psychiatry 2008;165(11):1442-1448. PDF Full Text