The image depicts the structure of MHETase bound to a non-hydrolyzable PET-derived ligand (MHETA). Symbolic polymer fibers connect MHETA to a typical PET bottle, indicating the large potential of enhanced PETase and MHETase variants in enzymatic plastic recycling. In this regard, our structural data facilitated the generation of initial MHETase variants with improved activity and extended substrate specificity. Our findings thus represent an important step on the way to an improved PETase / MHETase system where PET recycling is decoupled from its dependence on crude oil in an energy-saving and sustainable manner.
Martin Künsting/HZB