Research Links ARBs To Increased Risk Of Cancer. June 14, 2010.The AP (6/14,
Cheng) reports that, "in an analysis of
five previous studies following about 60,000 patients, experts found a link
between people taking medicines known as angiotensin-receptor blockers, or ARBs,
and cancer." Investigators "researchers found that people who took the drugs had
about a one percent higher risk of getting cancer than people who weren’t on the
drugs. This included a whole range of cancers – prostate, breast and a
noticeable spike in lung cancer." The research is published online in the Lancet
Oncology.The Cleveland
Plain Dealer (6/14, Townsend) reports, however, that the researchers
said "We need more studies. We need more analysis to further clarify the
risk."The UK’s Daily
Mail (6/14, Martin) reports, "The findings showed that 7.2 per cent of
patients taking ARBs were diagnosed with a new cancer over a period of four
years, compared with six per cent of patients not treated with the drugs." The UK’s Press
Association (6/14) reports that "more than 85% of the patients were
taking one type of ARB, telmisartan." Bloomberg
News (6/14, Matsuyama) reports, however, that "Astellas Pharma Inc. and
Boehringer Ingelheim GmbH said" that "telmisartan…is safe based on patient
studies, refuting" the new "finding." MedPage
Today (6/13, Smith) reported that the researchers "said their analysis
was prompted by the result of a 2003 trial of one of the drugs, which showed an
unexpected increase in the proportion of fatal cancers among those getting the
medication." BBC
News (6/14, Wilkinson) reports that "it is not clear why ARBs may
increase cancer risk, but some animal studies suggest there may be a link with
blood vessel growth in tumours."The CNN (6/13,
Falco) "Paging Dr. Gupta" blog reported that "in an accompanying editorial,
Dr. Steven Nissen, chairman of the Department of Cardiovascular Medicine at the
Cleveland Clinic…suggests the results of this analysis require ‘urgent
regulatory review.’" But, "Dr. Nicholas Vogelzang, an expert on several cancers
and spokesman for the American Society of Clinical Oncology disagrees. He says
he’s fairly skeptical about the study conclusion, because the only statistically
significant rise was in lung cancer." The Wall
Street Journal (6/14, Loftus), Reuters (6/14,
Steenhuysen), HeartWire (6/13,
Nainggolan), and HealthDay (6/13,
Edelson) also covered the story. .